Duquesne University of the Holy Spirit is a private Catholic university in Pittsburgh, Pennsylvania, United States. Founded by members of the Congregation of the Holy Spirit, Duquesne (pronounced /djuːˈkeɪn/, locally /duːˈkeɪn/ dew-kayn) first opened its doors as the Pittsburgh Catholic College of the Holy Ghost in October 1878 with an enrollment of 40 students and a faculty of six. In 1911, the college became a university, the first Catholic institution of higher learning in Pennsylvania to achieve such a distinction. It is the only Spiritan institution of higher education in the world. Duquesne has since expanded to over 10,000 graduate and undergraduate students within a self-contained 49-acre (19.8 ha) hilltop campus in Pittsburgh's Bluff neighborhood. The school maintains associate campuses in Harrisburg and Rome and encompasses ten schools of study. The university hosts international students from more than 80 countries although most students are from Pennsylvania—about 80%—or the surrounding region. U.S. News and World Report's annual college rankings place Duquesne in the top tier among national universities, with the school ranking 120th among national universities.