Osaka University (大阪大学, Ōsaka daigaku), or Handai (阪大, Handai), is a major national university located in Osaka, Japan. It is the sixth oldest university in Japan as the Osaka Prefectural Medical College, and formerly one of the Imperial Universities of Japan. Numerous prominent scientists worked at the Osaka University such as the Nobel Laureate in Physics Hideki Yukawa. Osaka University traces its origin back to 1869 when Osaka Prefectural Medical School was founded in downtown Osaka. The school was later transformed into the Osaka Prefectural Medical College with university status by the University Ordinance (Imperial Ordinance No. 388 of 1918) in 1919. The college merged with the newly-founded College of Science to form Osaka Imperial University（大阪帝國大学） in 1931. Osaka Imperial University was inaugurated as the sixth imperial university in Japan. As part of the University, Osaka Technical College was later included to form the school of Engineering two years later. The university was eventually renamed Osaka University in 1947.