The University of the Philippines Manila (U.P. Manila), founded in 1908, is a public research university in the Philippines. It is the oldest of the seven constituent universities of the University of the Philippines System (UP). It is located in Manila, the capital of the Philippines. Its oldest degree-granting unit is the College of Medicine, which was founded in 1905 as the Philippine Medical School, predating the founding of UP by three years. It is the center of health sciences education in the country, with the establishment of the National Health Sciences Center. It is also a reputable research center in the health sciences in the Asia-Pacific rim. It exercises administrative supervision over the Philippine General Hospital, the largest medical center and the national referral center for health in the Philippines, National Institutes of Health, Ugnayan ng Pahinungod, and Continuing Education. UP Manila is a reputable school of tertiary learning in the health sciences, and more high school students interested in this field apply to it than any other college or university in the country.